No, supplements don't lose their effectiveness. In fact, they offer the nutritional minerals and vitamins that our body needs to function properly. Sometimes our diet is not able to meet our nutritional requirements. In these cases, supplements help the body.
However, in general, Manson says, “a supplement can never replace a healthy diet. Most people don't need to take vitamin supplements and can get all the vitamins and minerals they need if they eat a healthy, balanced diet. Too much vitamin intake may not be a good idea for your wallet or your health. In addition to supplements, SPI is often found in energy bars, veggie burgers, and some soups, sauces, smoothies, and breakfast cereals.